TABLE 2.
Patient Characteristics after Adjustment with Inverse Probability of Treatment Weights
| Characteristic | LOF- Clopidogrel (n=226) | LOF- Alternative (n=346) | Standardized differences* | Non-LOF (n=1243) | LOF- Alternative (n=345) | Standardized differences* |
|---|---|---|---|---|---|---|
| Age | 62.7 ± 11.7 | 62.5 ± 11.4 | 0.02 | 62.5 ± 11.8 | 62.3 ± 11.6 | 0.01 |
| Male | 150 (67.5) | 237 (68.9) | 0.03 | 836 (67.6) | 229 (67.0) | 0.01 |
| Race | ||||||
| White | 166 (75.2) | 263 (76.4) | 0.03 | 968 (78.2) | 266 (77.7) | 0.01 |
| Black | 39 (17.6) | 55 (15.9) | 0.05 | 193 (15.6) | 53 (15.6) | 0.00 |
| BMI | 30.2 ± 6.3 | 30.1 ± 7.3 | 0.01 | 29.8 ± 5.9 | 29.8 ± 6.9 | 0.00 |
| Current smoker | 69 (31.4) | 107 (31.2) | 0.00 | 363 (29.4) | 97 (28.5) | 0.02 |
| PCI indication | ||||||
| Stable angina | 65 (28.2) | 100 (29.4) | 0.03 | 376 (30.4) | 101 (29.6) | 0.02 |
| ACS | 148 (67.0) | 232 (67.3) | 0.01 | 828 (66.9) | 233 (67.9) | 0.02 |
| Stent type | ||||||
| Drug eluding | 185 (84.3) | 290 (83.8) | 0.01 | 1040 (84.1) | 290 (84.8) | 0.02 |
| Bare metal | 34 (15.0) | 48 (14.1) | 0.03 | 182 (14.7) | 48 (14.0) | 0.02 |
| Medical history | ||||||
| Hypertension | 168 (76.0) | 273 (76.4) | 0.01 | 986 (79.7) | 271 (79.2) | 0.01 |
| Diabetes | 81 (36.8) | 121 (35.3) | 0.03 | 466 (37.6) | 124 (36.2) | 0.03 |
| Dyslipidemia | 153 (69.1) | 236 (68.5) | 0.01 | 837 (67.6) | 232 (67.7) | 0.00 |
| GFR† | 74.0 ± 27.7 | 74.7 ± 31.5 | 0.02 | 74.5 ± 28.1 | 75.2 ± 31.6 | 0.02 |
| MI | 60 (27.1) | 92 (26.8) | 0.01 | 313 (25.4) | 88 (25.8) | 0.01 |
| Revascularization | 95 (43.2) | 147 (42.9) | 0.05 | 143 (41.8) | 525 (42.4) | 0.01 |
| Heart failure | 32 (14.8) | 51 (14.8) | 0.00 | 166 (13.5) | 45 (13.2) | 0.01 |
| Stroke or TIA | 23 (10.7) | 33 (9.7) | 0.03 | 114 (9.2) | 28 (8.3) | 0.03 |
| PVD | 21 (9.3) | 31 (9.0) | 0.01 | 99 (8.0) | 26 (7.6) | 0.01 |
| Medication use | ||||||
| Aspirin | 217 (98.3) | 339 (98.4) | 0.01 | 1216 (98.2) | 336 (98.2) | 0.00 |
| PPI | 69 (31.4) | 109 (31.7) | 0.01 | 398 (32.2) | 106 (30.9) | 0.05 |
| Anticoagulant | 19 (8.9) | 28 (8.2) | 0.03 | 98 (8.0) | 24 (7.3) | 0.03 |
| Statin | 209 (94.3) | 325 (94.5) | 0.01 | 1149 (92.8) | 319 (93.3) | 0.02 |
| ACEi/ARB | 149 (67.4) | 231 (67.3) | 0.00 | 817 (66.0) | 224 (65.4) | 0.01 |
| Beta blocker | 180 (81.5) | 282 (81.8) | 0.01 | 1055 (85.3) | 291 (85.0) | 0.01 |
No. (%) or mean ± SD
ACEi, angiotensin converting enzyme inhibitor; ACS, acute coronary syndrome; ARB, angiotensin receptor blocker; BMI, body mass index; GFR, glomerular filtration rate; MI, myocardial infarction; PCI, percutaneous coronary intervention; PPI, proton pump inhibitor; PVD, peripheral vascular disease; TIA, transient ischemic attack
*
Weighted absolute standardized differences are calculated using stabilized inverse probability of treatment weighting. All values are less than 0.1, which indicate elimination of imbalance between the two groups.
†
Estimated creatinine clearance using Cockcroft-Gault formula