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. Author manuscript; available in PMC: 2019 Jan 19.
Published in final edited form as: Circ Res. 2017 Dec 12;122(2):282–295. doi: 10.1161/CIRCRESAHA.117.310725

Figure 5. β1-AR signaling induces mitochondrial fragmentation in HL-1 cells.

Figure 5

Cells were treated with ISO (10μM) for 1h and imaged by confocal microscopy. ISO increased mitochondrial fragmentation (decreased perimeter and area and increased number), and this was blocked by CGP12177 (β1-antagonist) but not by ICI118551 (β2-antagonist) (n=13–25 cells/group). Cells were quantified using a custom macro in Image J.