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. Author manuscript; available in PMC: 2019 Jan 19.
Published in final edited form as: Circ Res. 2017 Dec 12;122(2):282–295. doi: 10.1161/CIRCRESAHA.117.310725

Figure 6. β1-AR signaling enhances mitochondrial respiration in HL-1 cells, which is opposed by both β2-AR and β3-AR signaling.

Figure 6

(A) ISO increased basal, maximal and ATPase-driven respiration in a dose-dependent manner starting at 1μM (n=5/group). (B) This increase was blocked by CGP and further increased by ICI (n=4/group). ISO increased Drp1 mitochondrial translocation, which was blocked by CGP. ISO also significantly increased ATP production (n=7/group). (C) ISO enhanced respiration was synergistically increased with the β3AR antagonist L748,337 and blocked with propranolol (β1/β2 antagonist) (n=5/group). (D) Inhibition of mitochondrial fission with Mdivi-1 blocked ISO-induced increased in mitochondrial respiration (n=5/group).