Table 1.
Prevalence of genetic variants and their risk analysis for high OPR.
| N (%) | Adjusted OR (95% CI)* | p-value | ||
|---|---|---|---|---|
| CYP2C19 | *1/*1 | 1682 (36.7) | Reference | |
| *1/*17 | 56 (1.2) | 1.71 (0.906–3.245) | 0.10 | |
| *1/*2 | 1610 (35.1) | 2.01 (1.675–2.418) | <0.01 | |
| *1/*3 | 561 (12.2) | 2.31 (1.818–2.933) | <0.01 | |
| *1/*R | 2227 (48.6) | 2.08 (1.749–2.466) | <0.01 | |
| *2/*17 | 33 (0.7) | 2.43 (1.094–5.396) | 0.03 | |
| *2/*2 | 342 (7.5) | 3.86 (2.943–5.062) | <0.01 | |
| *2/*3 | 245 (5.3) | 4.43 (3.265–6.022) | <0.01 | |
| *3/*17 | 9 (0.2) | 1.90 (0.375–9.646) | 0.44 | |
| *3/*3 | 49 (1.1) | 7.59 (4.135–13.935) | <0.01 | |
| *R/*R | 678 (14.8) | 4.14 (3.339–5.141) | <0.01 | |
| CYP2C9 | *1/*1 | 4226 (92.1) | Reference | |
| *1/*3 | 356 (7.8) | 0.76 (0.574–1.005) | 0.80 | |
| *3/*3 | 5 (0.1) | 0.78 (0.083–7.217) | 0.90 | |
| PON1 | RR | 552 (12.0) | Reference | |
| QR | 2172 (47.4) | 0.83 (0.659–1.035) | 0.08 | |
| 1863 (40.6) | 0.90 (0.719–1.136) | 0.95 | ||
| ABCB1 | CC | 1865 (40.7) | Reference | |
| CT | 2101 (45.8) | 1.05 (0.898–1.220) | 0.36 | |
| TT | 621 (13.5) | 0.95 (0.758–1.189) | 0.49 | |
| P2Y12 | GG | 3483 (75.9) | Reference | |
| GT | 1007 (22.0) | 1.00 (0.837–1.183) | 0.52 | |
| TT | 97 (2.1) | 1.19 (0.746–1.900) | 0.46 | |
*Odd ratio (OR) with 95% confidence interval (CI) was adjusted for age, sex, body mass index, current smoker, diabetes mellitus, prior coronary artery bypass graft, acute coronary syndrome, multivessel involvement, haemoglobin level, and creatinine level.