Table 3.
Degree of keratoconjunctival inflammation in guinea pig eyes infected with S. flexneri strains.
| Bacterial strain | 24 h | 48 h | 72 h | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 1 | 2 | 3 | 4 | 5 | 6 | 1 | 2 | 3 | 4 | 5 | 6 | |
| Sf301 | ++ | + | ++ | + | ++ | + | +++ | +++ | +++ | +++ | +++ | ++ | +++ | +++ | +++ | +++ | +++ | +++ |
| ΔphoPQ | – | – | – | – | – | – | – | – | + | – | – | – | – | + | + | – | + | – |
| ΔphoPQc | ++ | + | + | + | + | ++ | +++ | +++ | ++ | ++ | +++ | +++ | +++ | +++ | ++ | +++ | +++ | +++ |
| ΔicsA | – | + | + | – | + | – | + | + | + | – | + | + | + | ++ | + | – | + | ++ |
| ΔicsAc | ++ | ++ | + | ++ | + | + | +++ | +++ | ++ | +++ | ++ | ++ | +++ | +++ | ++ | +++ | +++ | ++ |
| ΔphoPQ(picsA) | + | ++ | + | + | + | + | ++ | ++ | ++ | ++ | ++ | + | ++ | +++ | ++ | ++ | +++ | ++ |
| PBS | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
The degree of keratoconjunctival inflammation in each of the six guinea pigs infected with S. flexneri strains and PBS at 24, 48, and 72 h (n = 6). Guinea pig keratoconjunctivitis test was rated as follows: –, no disease or mild irritation; +, mild conjunctivitis or late development and/or rapid clearing of symptoms; ++, keratoconjunctivitis without purulence; and +++, fully developed keratoconjunctivitis with purulence.