Table 2.
Correlations of clinical rating scales, disease characteristics, and selected oculomotor parameters in Gaucher disease type 3 patients.
| Disease duration | IQ | Peak velocity of downward saccades | Duration of vertical saccades | Gaze-holding (slow-phase velocity) | Quick phases (2D vector) | Gain of upward smooth pursuit | Gain of downward smooth pursuit | Gain of horizontal smooth pursuit | Gain of horizontal aVOR | Gain of horizontal aVOR to the right | Slopes of vertical saccades | Slopes of horizontal saccades | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SARA | ρ = 0.588, p = 0.027 | ρ = −0.779, p = 0.001 | ρ = −0.752, p < 0.0005 | ρ = 0.806, p < 0.001 | Vertical component in the center: ρ = −0.803, p = 0.001 | Center frequency: ρ = 0.676, p = 0.008 | NS | 0.1 Hz | NS | ρ = −0.63, p = 0.016 | ρ = −0.614, p = 0.009 | NS | NS |
| Vertical component down: ρ = −0.772, p = 0.001 | ρ = 0.563, p = 0.036 | ||||||||||||
| mSST | ρ = 0.536, p = 0.048 | ρ = −0.804, p = 0.001 | ρ = −0.611, p = 0.003 | ρ = 0.700, p < 0.0005 | Vertical component in the center: ρ = −0.804, p = 0.002 | Center frequency: ρ = 0.688, p = 0.013 | NS | 0.1 Hz | NS | ρ = −0.725, p = 0.003 | ρ = −0.677, p = 0.008 | NS | NS |
| Vertical component down: ρ = −0.609 p = 0.036 | ρ = 0.538, p = 0.047 | ||||||||||||
| Horizontal component in the center: ρ = 0.694, p = 0.01 | |||||||||||||
| Horizontal component right: ρ = 0.705, p = 0.01 | |||||||||||||
| Bimanual GPT z-scores (dominant vs. non-dominant hand) | NS | ρ = −0.785, p = 0.004 | ρ = −0.649, p = 0.005 | ρ = 0.558, p = 0.02 | Vertical component in the center: ρ = −0.809, p = 0.003 | NS | NS | NS | Dominant hand: 0.1 Hz: ρ = −0.627, p = 0.039 0.2 Hz: ρ = −0.773, p = 0.005 |
ρ = −0.666, p = 0.004 | ρ = −0.918, p < 0.001 | NS | NS |
| Horizontal component right: ρ = 0.673, p = 0.023 | Non-dominant hand:0.1 Hz: NS, 0.2 Hz: ρ = −0.606, p = 0.048 | ||||||||||||
| Disease duration | – | NS | NS | NS | NS | Down: frequency | 0.2 Hz | NS | NS | NS | NS | NS | NS |
| ρ = 0.527, p = 0.03 | ρ = 0.439, p = 0.047 | ||||||||||||
| Age at onset | – | NS | NS | NS | Vertical component left: ρ = −0.555, p = 0.021 | Center: peak velocity | 0.1 Hz: ρ = 0.435, p = 0.049 | NS | NS | NS | NS | NS | NS |
| Vertical component down: ρ = −0.579, p = 0.015 | ρ = −0.661, p = 0.004 | 0.2 Hz: ρ = 0.552, p = 0.009 | |||||||||||
| Horizontal component center: ρ = −0.713, p = 0.001 | |||||||||||||
| Horizontal component right: ρ = −0.512, p = 0.036 | |||||||||||||
| Horizontal component down: ρ = −0.804, p < 0.001 | |||||||||||||
| Slopes of downward saccades | NS | ρ = −0.720, p = 0.005 | – | – | Vertical component in the center: ρ = −0.559, p = 0.03 | Center: frequency | NS | NS | NS | ρ = −0.556, p = 0.017 | ρ = −0.632, p = 0.005 | – | NS |
| Vertical component left: ρ = −0.625, p = 0.013 | ρ = 0.511, p = 0.051 | ||||||||||||
| Slopes of vertical saccades | NS | ρ = −0.740, p = 0.002 | – | – | Vertical component in the center: ρ = −0.733, p = 0.001 | Center: frequency | NS | NS | NS | ρ = −0.632, p = 0.005 | ρ = −0.767, p < 0.001 | – | NS |
| Vertical component left: ρ = −0.663, p = 0.004 | ρ = 0.674, p = 0.003 | ||||||||||||
| Horizontal component right: ρ = −0.513, p = 0.035 | |||||||||||||
| Vertical component down: ρ = −0.544, p = 0.024 | |||||||||||||
| Slopes of horizontal saccades | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | – |
| Age | – | NS | NS | NS | Horizontal component straight ahead: ρ = −0.498, p = 0.042 | NS | 0.1 Hz: ρ = 0.510, p = 0.018 | 0.2 Hz: ρ = 0.466, p = 0.033 | 0.1 Hz: ρ = 0.425, p = 0.055; | NS | NS | NS | NS |
| Horizontal component in the left position: ρ = −0.618, p = 0.008 | 0.2 Hz: ρ = 0.554, p = 0.009 | 0.2 Hz: NS | |||||||||||
| Horizontal component in the down position: ρ = −0.651, p = 0.005 | |||||||||||||
Only significant results are shown.
GPT, Grooved Pegboard Test; mSST, modified Severity Scoring Tool; NS, not significant; OKN, optokinetic nystagmus; p, level of significance; ρ, Spearman correlation coefficient; VOR, vestibulo-ocular reflex; SARA, Scale for the Assessment and Rating of Ataxia.