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. 2018 Jan 15;8:995. doi: 10.3389/fphar.2017.00995

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Copyright © 2018 Gao, Liang, Fang, Zhao, Tian, Zhang and Qin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Different metabolites and corresponding pathways in CUMS rats or healthy rats following PBR administration. “↑” and “↓” represent that the metabolite is up- or down-regulated in CUMS rats or healthy rats folloowing PBR administration. In CUMS rats following PBR administration ([C4], [C6], and [C7]), glycometabolism and amino acid metabolism were up-regulated; however, glycerophospholipid metabolism, sphingolipid metabolism and fatty acid metabolism were down-regulated, all being compared with the corresponding group without drug treatment [CM]. In healthy rats following PBR administration ([Z4], [Z6], and [Z7]), lysine degradation and bile acid metabolism were up-regulated; however, the other three pathways of glycerophospholipid metabolism, sphingolipid metabolism and fatty acid metabolism were up- or down-regulated, all being compared with the corresponding group without drug treatment [K].