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. 2018 Jan 15;8:995. doi: 10.3389/fphar.2017.00995

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Copyright © 2018 Gao, Liang, Fang, Zhao, Tian, Zhang and Qin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Normalized intensity levels of potential biomarkers in serum samples of normal rats ( $◼$ red), and the relative content of the corresponding metabolites in CUMS rats ( $◼$ blue). D0: administration of equal volumes of vehicle. D4: the concentration of PBR was 1.25 g/ml (expressed as the weight of raw materials). D6: the concentration of PBR was 5.0 g/ml. D7: the concentration of PBR was 10.0 g/ml. Data are presented as mean ± SEM. n = 8 each group. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 vs. [CM] group; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 vs. [K] group. (B): the relative content of the heatmap of differential metabolites in serum samples of healthy rats with PBR administration. Class K: the [K] group. Class Z4: the [Z4] group. Class Z6: the [Z6] group. Class Z7: the [Z7] group. The ribbon −3~3: represents the relative content of the differential metabolites from low to high.