. 2018 Jan 15;8:995. doi: 10.3389/fphar.2017.00995

Table 1.

Identified differential metabolites in the serum of CUMS rats with or without administration of PBR.

No.	Metabolites	T_R (min)	m/z	ion	CM/K	C7/CM	C6/CM	C4/CM	Metabolic pathway
C1	4-Acetamidobutanoic acid	1.18	146.0812	M+H	↓^a	↑^a	↑^a	↑^a	Arginine and proline metabolism
C2	Glucose/Galactose^b	1.34	179.0553	M-H	↓^a	↑	↑	↑^a	Glycometabolism
C3	Leucine^b	3.01	132.1025	M+H	↓^a	↑^a	↑^a	↑^a	Amino acid metabolism
C4	Isoleucine ^b	3.22	132.1025	M+H	↓^a	↑^a	↑^a	↑^a	Amino acid metabolism
C5	Valine^b	1.67	118.0864	M+H	↓^a	↑^a	↑^a	↑^a	Amino acid metabolism
C6	Tryptophan^b	5.99	205.0976	M+H	↓^a	↑^a	↑	↑	Tryptophan metabolism
C7	Glutamic acid^b	1.38	146.0453	M-H	↓^a	↑^a	↑^a	↑	Amino acid metabolism
C8	3-Indolepropionic acid	9.71	190.0868	M+H	↑^a	↓^a	↓	↓^a	Tryptophan metabolism
C9	LysoPC (16:0)	25.13	496.3402	M+H	↑^a	↓	↓	↓^a	Glycerophospholipid metabolism
C10	LysoPC (18:0)	27.65	524.3715	M+H	↑^a	↓	↓	↓^a	Glycerophospholipid metabolism
C11	LysoPC (22:5)	28.30	568.3618	M-H	↑^a		↓	↓^a	Glycerophospholipid metabolism
C12	LysoPC(20:3)	25.24	546.3531	M+H	↑^a	↓^a	↓^a	↓^a	Glycerophospholipid metabolism
C13	LysoPC(15:0)	28.36	482.3245	M+H	↑^a	↓^a	↓^a	↓^a	Glycerophospholipid metabolism
C14	LysoPE[0:0/18:1(9Z)]	26.24	480.3452	M+H	↑^a	↓^a	↓^a	↓^a	Glycerophospholipid metabolism
C15	3-O-Sulfogalactosylceramide (d18:1/22:0)	23.82	862.5595	M-H	↑^a	↓^a	↓^a	↓^a	sphingolipid metabolism
C16	Sphinganine	18.02	302.3058	M+H	↑^a	↓^a	↓^a	↓^a	sphingolipid metabolism
C17	Cer(d18:0/16:0)	30.08	540.5354	M+H	↑^a	↓^a	↓	↓	sphingolipid metabolism
C18	Cer(d18:0/18:0)	30.90	568.5667	M+H	↑^a	↓^a	↓	↓	sphingolipid metabolism
C19	13s-Hydroxyoctadecadienoic acid	22.65	297.2431	M+H	↑^a	↓^a		↓^a	Fatty acid metabolism
C20	10Z-Heptadecenoic acid	28.57	267.2112	M-H	↑^a	↓^a		↓^a	Fatty acid metabolism
C21	N-Heptanoylglycine	9.11	186.0553	M-H	↑^a	↓^a			β-oxidation of fatty acid
C22	Palmitoylcarnitine	22.08	400.3426	M+H	↑^a	↓^a	↓^a	↓^a	β-oxidation of fatty acid
C23	Octadecenylcarnitine	22.72	426.358	M+H	↓^a				β-oxidation of fatty acid

↑shows up-regulated metabolite; ↓shows down-regulated metabolite.

Means a statistically significant difference at p < 0.05.

Validated with standard. [CM] group compared with [K] group, CM/K; [C4] group compared with [CM] group, C4/CM; [C6] group compared with [CM] group, C6/CM; [C7] group compared with [CM] group, C7/CM.