. 2018 Jan 15;8:995. doi: 10.3389/fphar.2017.00995

Table 2.

Identified differential metabolites in the serum of healthy rats with or without administration of PBR.

No.	Metabolites	T_R (min)	m/z	ion	Z4/K	Z6/K	Z7/K	Metabolic pathway
Z1	LysoPC(20:4)	18.92	544.2673	M+H	↑^a	↑^a	↑^a	Glycerophospholipid metabolism
Z2	LysoPC(20:3)	25.24	546.3531	M+H	↓	↓	↓^a	Glycerophospholipid metabolism
Z3	LysoPC[16:1(9Z)]	22.66	494.3248	M+H			↑^a	Glycerophospholipid metabolism
Z4	LysoPC(17:0)	26.78	510.3564	M+H	↑	↑	↑^a	Glycerophospholipid metabolism
Z5	LysoPC(20:0)	30.79	552.4027	M+H	↑	↑	↑^a	Glycerophospholipid metabolism
Z6	LysoPE[0:0/18:1(9Z)]	26.24	480.3452	M+H		↓^a	↓^a	Glycerophospholipid metabolism
Z7	LysoPC(15:0)	27.73	482.3245	M+H		↓^a	↓^a	Glycerophospholipid metabolism
Z8	Sphinganine 1-phosphate	22.44	382.2721	M+H	↑^a	↑^a	↑^a	sphingolipid metabolism
Z9	sphinganine	18.02	302.3058	M+H		↓^a		sphingolipid metabolism
Z10	CerP(d18:1/26:1)	30.70	784.5778	M+H	↓^a		↓^a	sphingolipid metabolism
Z11	Cer(d18:0/16:0)	30.08	540.5354	M+H		↓^a	↓^a	sphingolipid metabolism
Z12	Cer(d18:0/18:0)	30.90	568.5667	M+H		↓	↓^a	sphingolipid metabolism
Z13	Cer(d18:0/20:0)	31.75	596.5979	M+H		↓^a	↓^a	sphingolipid metabolism
Z14	Octadecenylcarnitine	22.72	426.358	M+H	↓	↓^a	↓^a	β-oxidation of fatty acid
Z15	Stearoylcarnitine	24.55	428.374	M+H		↓^a	↓^a	β-oxidation of fatty acid
Z16	Palmitoylcarnitine	22.08	400.3426	M+H		↓^a	↓^a	β-oxidation of fatty acid
Z17	Taurocholic acid ^b	16.80	514.221	M-H	↑^a	↑^a	↑^a	bile acid metabolism
Z18	Glycocholic acid ^b	14.97	464.3014	M-H	↑	↑	↑^a	bile acid metabolism
Z19	20-Oxo-leukotriene E4	24.45	454.2932	M+H			↓^a	leukotriene metabolism
Z20	20-COOH-leukotriene E4	16.79	470.2309	M+H	↑^a	↑^a	↑^a	leukotriene metabolism
Z21	2-Keto-6-acetamidocaproate	6.01	188.0706	M+H	↑		↑^a	Lysine metabolism
Z22	(S)-2-amino-6-oxohexanoate	5.52	144.045	M-H	↑		↑^a	Lysine metabolism
Z23	α-12(13)-EpODE	16.01	293.1756	M-H	↑^a	↑^a	↑^a	lipid metabolism

↑ shows up-regulated metabolite; ↓ shows down-regulated metabolite.

Means a statistically significant difference at p < 0.05.

Validated with standard. [Z4] group compared with [K] group, Z4/K; [Z6] group compared with [K] group, Z6/K; [Z7] group compared with [K] group, Z7/K.