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. 2018 Jan 15;11:435. doi: 10.3389/fncel.2017.00435

FIGURE 2.

FIGURE 2

Adenosine A1 receptors inhibit DDI. (A) Application of adenosine (100 μM) reduced DDI evoked by depolarization (0 mV, 50 ms) in NMRI wild-type mice. (B) Time course of adenosine-evoked reduction in DDI. (C) The effect of adenosine on DDI was significant and reversible. (D) DPCPX (1 μM) entirely inhibited the effect of adenosine on DDI. (E) Time course of DDI in the presence of DPCPX. (F) Adenosine failed to inhibit DDI in the presence of DPCPX. (G) In A1 receptor knock-out mice (A1-/-), adenosine failed to reduce DDI. (H) Time course of DDI during application of adenosine (100 μM) in A1 receptor knock-out mice and wild-type littermates (A1+/+). (I) DDI in the presence of adenosine was significantly reduced in wild-type mice, but not in knock-out littermates. n.s., not significant; ∗p < 0.05; ∗∗p < 0.01.