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. 2018 Jan 19;9:301. doi: 10.1038/s41467-017-02745-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — AU-rich elements modulate repression by Pumilio and miRNAs. a The position of an ARE within the synthetic 3′UTR determines the relative TE or RNA expression. b The relative 40s association of ARE containing reporters. c Heatmap of the regression coefficients for the parameters corresponding to AREs alone. Left panel shows coefficients for RNA expression and the right panel shows coefficients for TE. d AREs modulate repression by miRNAs in a position-dependent manner. The green box highlights an example of stimulation of miRNA-mediated RNA destabilization by an ARE. e The regression coefficients for the parameters corresponding to let-7 or AREs alone or interactions between positions containing let-7 or ARE. f AREs modulate repression by PREs in a position dependent manner. g The regression coefficients for the parameters corresponding to PREs or AREs alone or interactions between positions containing PRE or ARE. For a, b, d and f, * = Blank, A = ARE, L = let-7 and p = PRE. For c, e and g, *P < 0.05, **P < 0.01, ***P < 0.001, t-test. Boxplot whiskers indicate the furthest datum that is 1.5*Q1 (upper) or 1.5*Q3 (lower). For clarity, outliers have been removed from boxplots but were used for statistical analysis