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. 2018 Jan 19;8:1242. doi: 10.1038/s41598-018-19668-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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A representative case. A 66-year-old male patient who experienced a small cerebral infarction in the left frontal lobe and was found to have an occlusion of the left internal carotid artery by MRA (a). The ¹⁵O-labelled gas PET study revealed a reduced rCBF (rCBF ratio was 0.58) (b) and an elevated rOEF (rOEF ratio was 1.18) (c) in the target regions of interest (red circles). (d) The NIRS/ICG measurement provided an ICG time-intensity curve from the left site (blue line) as well as the right site (red line). the calculated ΔICGmax ratio was 0.83, TTP ratio was 1.10, the RT ratio was 1.30, and the BFI ratio was 0.64.