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. 2018 Jan 15;8:233. doi: 10.3389/fgene.2017.00233

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Copyright © 2018 Prince and Rand.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Multidrug Resistance Protein (MRP) upregulation in myogenic lineages conveys MeHg tolerance during development. (A) Expression of MRP, a xenobiotic and MeHg transporter, was assessed by crossing UAS-MRP (MRP^EY11919) with Actin-GAL4 and conducting RT-qPCR on RNA extracted from pupal offspring (^****p < 0.0001, t-test). Tolerance to MeHg during development was determined using an eclosion assay, with offspring of control (YW) or UAS-MRP flies crossed to various driver lines: (B) NP1-G4 (gut driver), (C) ELAV-G4 (neural driver), and (D) Mef2-G4 (muscle driver). Asterisks mark statistical significance in comparison to control at each treatment (^*p ≤ 0.05, ^**p ≤ 0.01, ^****p < 0.0001, z-test).