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. 2018 Jan 19;8:1263. doi: 10.1038/s41598-018-19750-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mitochondrial regulatory proteins and mitochondrial DNAs. (A) After Antimycin A (AMA) exposure, the expression of dynamin-related protein1 (DRP1) in PK1 mitochondria increased significantly, but was attenuated by STC-like cells-EV. No significant changes were observed in fusion-related proteins Mitofusin 2 (Mfn2) and Optic Atrophy-1 (OPA1). (B) Pro-apoptosis caspase3 evaluated after AMA treatment in PK1, and EV down-regulated its expression. There was no change of Bax/Bcl-XL ratio. (C) ND1 and COXIII DNAs decreased significantly after AMA treatment in PK1. STC-like cells-EV contained mtDNAs and improved its expression in injured PK1 (*P < 0.05 vs PK1, ^#P < 0.05 vs PK1 + AMA). The representative Western blots were cropped from the different parts of the same gel, and the full-length blots can be found in Supplementary info file.