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. 2018 Jan 19;8:1187. doi: 10.1038/s41598-018-19459-y

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© The Author(s) 2018, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Delayed functional maturation of visual cortex in IE rats. (a) Visual acuity (VA) of IE animals was significantly decreased compared to that of SC rats at P28 (SC P28, n = 6; IE P28, n = 6; Two Way ANOVA, post-hoc Holm-Sidak method, p < 0.001), P32 (SC P32, n = 5; IE P32, n = 7; p < 0.001) and P35 (SC P35, n = 5; IE P35, n = 6, p < 0.05) but not at P21 (SC P21, n = 3; IE P21, n = 6; Two Way ANOVA, post-hoc Holm-Sidak method, p = 0.09) and P45 (SC P45, n = 6; IE P45, n = 5; post-hoc Holm-Sidak method, p = 0.81). Symbols represent average VA values ± SEM. Error bars are smaller than the size of the symbols for some data points. (b,c) At P28 and P32 VEP latency of IE rats was increased with respect to SC animals at 0.1 c\deg, 0.2 c\deg, 0.3 c\deg, 0.4 c\deg, 0.5 c\deg and 0.6 c\deg (Two way RM ANOVA, post-hoc Holm-Sidak method, p < 0.05 for all comparisons). (d) At P35 P100 latency of IE rats was increased with respect to SC animals at 0.4 c\deg, 0.5 c\deg and 0.6 c\deg (Two way RM ANOVA, post-hoc Holm-Sidak method, p < 0.05 for all comparisons, except for p < 0.01 at 0.5 c/deg). e) VEP latencies at P45 were not different between SC and IE animals (Two way RM ANOVA, p = 0.42). Histograms represent latency average values ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001.