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. 2018 Jan 19;8:1187. doi: 10.1038/s41598-018-19459-y

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© The Author(s) 2018, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IE affects IGF-1 expression in the visual cortex. (a) Representative examples of IGF-1 labeling from fields taken in the layers V/VI of the visual cortex of SC and IE rats at P12, P18 and P21. Calibration bar: 50 µm. (b) Number of IGF-1 positive (IGF-1⁺) cells/mm² in the visual cortex of SC and IE animals. IGF-1⁺ cell density was lower in IE animals at P12 (SC P12, n = 7; IE P12, n = 4) and P18 (SC P18, n = 6; IE P18, n = 6; Two Way ANOVA, post-hoc Holm-Sidak method, p < 0.05 for both comparisons). The number IGF-1⁺ cells did not differ between SC and IE at P21 (SC P21, n = 5; IE P21, n = 5; Two Way ANOVA, post-hoc Holm-Sidak method, p = 0.48). Symbols represent average values ± SEM. *p < 0.05.