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. 2018 Jan 19;8:1187. doi: 10.1038/s41598-018-19459-y

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© The Author(s) 2018, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IE delays axonal myelination in the visual cortex. (a) Left: Example of MBP labeling from fields taken in layers V/VI of the visual cortex of P12 SC and IE rats. Calibration bar: 50 μm. Right: Quantitative analysis of MBP immunofluorescence intensity in layers V/VI of the visual cortex of P12 animals. SC animals showed higher MBP expression in comparison to IE animals in the layers V/VI (SC P12, n = 4; IE P12, n = 6; Mann-Whitney Rank Sum Test, p < 0.05). (b–d) Left: Example of MBP labeling from fields taken through all layers of the visual cortex in P18, P28 and P35 SC and IE rats. Calibration bar: 100 μm. Right: Quantitative analysis of MBP immunofluorescence intensity in all layers of the visual cortex of P18, P28 and P35 animals. At P18 SC animals showed higher MBP immunofluorescence in layers V/VI and IV (SC P18, n = 5; IE P18, n = 6; Two way RM ANOVA, Post-hoc Holm-Sidak method, p < 0.05). At P28 SC animals showed higher MBP expression in comparison to IE animals in the layers IV and II-III (SC P28, n = 6; IE P28, n = 6; Two way RM ANOVA, Post-hoc Holm-Sidak method, p < 0.05). The layers V-VI were completely myelinated and MBP expression did not differ between groups (p = 0.74). At P35 MBP immunofluorescence did not differ between SC and IE animals in any cortical layer (SC P35, n = 5; IE P35, n = 6; Two way RM ANOVA, p = 0.63). Histograms represent average values ± SEM. *p < 0.05.