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. 2018 Jan 19;8:1211. doi: 10.1038/s41598-017-18100-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HDL receptor, SCARB1, is overexpressed in sonic hedgehog driven medulloblastoma and high expression predicts poor survival. (a) SCARB1 expression was analysed in different medulloblastoma subtypes from the Northcott dataset³⁰, one-way ANOVA, **P ≤ 0.01, ****P ≤ 0.0001. (b) Percent of patients in different subtypes from the Northcott dataset with SCARB1 > 1 Log2 FC relative to the median expression. (c) Differential expression analysis of medulloblastoma patient samples with high vs. low SCARB1 expression from the Northcott dataset. (d) Heatmap showing differential expression in medulloblastoma patients as in (c). (e–i) Gene expression data was analysed by correlation analysis. SCARB1 expression is compared with five SHH pathway genes GLI1 (e), GLI2 (f), GLI3 (g), HHIP (h) and BMP5 (i). Pearson’s correlation coefficients are shown, ****P ≤ 0.0001. (j) Survival data from the Pomeroy dataset³¹ was analysed by Kaplan Meier curve comparison (n = 62). Log-rank (Mantel-Cox), P = 0.0039.