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. 2018 Jan 19;8:1230. doi: 10.1038/s41598-018-19370-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Downregulation of Dot1L decreases nuclear translocation of NF-κB. A549 cells were used as control (control), or transduced with lentivirus expressing an irrelevant shRNA (TM) or specific Dot1L silencers (shDot1L 1, shDot1L 2). 5 days later, TNFα was added (10 ng/ml, 30 min). Cells were processed for immunofluorescence using anti-lamin A/C and -p65 antibodies. (B) Cells were processed as in (A) and PR8hv-infected (m.o.i. 3, 8 h). Immunofluorescence analysis were carried out using anti-NP, -lamin and -p65 antibodies. Three independent experiments were performed.