Table 3.

Adverse events reported by subjects with bipolar depression during a 6-week adjunctive treatment trial with creatine monohydrate or placebo

Adverse event	Creatine (N = 16)	Placebo (N = 11)	p a
	N (%)	N (%)
Pruritus	1 (6.3)	2 (18.2)	0.548
Cramps	1 (6.3)	1 (9.1)	1.000
Headache	2 (12.5)	6 (54.5)	0.033
Constipation	3 (18.8)	3 (27.3)	0.662
Diarrhea	2 (12.5)	1 (9.1)	1.000
Limb edema	2 (12.5)	2 (18.2)	1.000
Nausea	0 (0.0)	3 (27.3)	0.056
Vomiting	0 (0.0)	1 (9.1)	0.407
Reflux	1 (6.3)	2 (18.2)	0.549
Somnolence	1 (6.3)	3 (27.3)	0.273
Dizziness/vertigo	2 (12.5)	2 (18.2)	1.000
Asthenia	0 (0.0)	3 (27.3)	0.056
Abdominal pain	1 (6.3)	3 (27.3)	0.273
Other	1 (6.3)b	1 (9.1)c	1,000

^aCalculated by Fisher’s exact test

^bHeartburn

^cIncreased sweating