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. 2017 Nov 16;8(11):e3169. doi: 10.1038/cddis.2017.521

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Downregulation of FMRP in melanoma cells affects migration. (a) Wound-healing assay in 501 mel cells treated with FMR1 siRNA, with scrambled siRNA (scr siRNA) or untransfected cells (CTR). (Left panel) A single scratch was made in the center of cell monolayer and the wound closure areas visualized under an inverted microscope with a x20 magnification. (Right panel) Cell motility was quantified by measuring the distance between the invading front of cells in 10 random selected microscopic fields for each single condition and time point (right panel) (n=3, ***P<0.001, Student's t-test). (b) Same as in panel a for the A375 cell line. Calibration bars 250 μm in (a and b)