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. 2017 Nov 2;8(11):e3161. doi: 10.1038/cddis.2017.533

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Effect of bort on MΦs and MM cells. (a) Effect of bort on MΦs. Bort has small proapoptotic effect in MΦs. Values are presented as means±S.D. (b,c) ARP-1 and RPMI8226 cells were cultured alone or co-cultured with MΦs in the absence or presence of bort (5 and 10 nM for ARP-1 cells and RPMI8226, respectively; 24 h). Apoptosis was evaluated by flow cytometry with Annexin V/PI staining. (b) A representative result showing that MΦs reduced the bort-induced apoptosis of ARP-1 and RPMI8226 cells. (c) The protective effect of MΦs from different donors is analyzed as means±S.D. (d) A representative and summarized result showing that MΦs prevented spontaneous apoptosis of primary CD138+ plasma cells. Values are presented as means±S.D. (e,f) ARP-1 and RPMI8226 cells were cultured alone or co-cultured with MΦs in the absence or presence of Mel (15 and 20 μM for ARP-1 cells and RPMI8226, respectively; 24 h) or Pano (250 and 300 nM for ARP-1 cells and RPMI8226, respectively; 24 h). Apoptosis was evaluated by flow cytometry with Annexin V/PI staining. (e) A representative result showing that MΦs reduced apoptosis of ARP-1 and RPMI8226 cells from melphalan rather than panobinostat. (f) The protective effect of MΦs from different donors is analyzed as means±S.D.