Figure 1.

IL-33 expression is increased in the articular chondrocytes of osteoarthritic patients. (a–c) Quantification of Il-33 (a), Mmp-1 (b), and Mmp-13 (c) expression in articular tissues from normal and osteoarthritic patients. (d) Immunohistochemical analysis of IL-33 expression in articular tissue from normal and osteoarthritic patients. Scale bar represents 20 μm. (e–g) Quantification of IL-33 (e), MMP-1 (f), and MMP-13 (g) in normal and osteoarthritic cartilages detected by ELISA. (h) Western blot of IL-33 in normal and osteoarthritic cartilages. (i–k) Quantification of Il-33 (i), Mmp-1 (j), and Mmp-13 (k) expression in normal and osteoarthritic cartilages. (l–n) Quantification of IL-33 (l), MMP-1 (m), and MMP-13 (n) in synovial fluid of normal and osteoarthritic patients detected by ELISA. *P<0.05, **P<0.01, and ***P<0.001. P-values were analyzed by t-test