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. 2017 Nov 2;8(11):e3165. doi: 10.1038/cddis.2017.534

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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p65 and PPARγ transcriptional complex formation is required for dsRNA-induced IL-33 expression. (a) Quantification of IL-33 mRNA expression induced by 10 μg/ml poly(I:C) in the presence of the PPARγ inhibitor GW9662. (b,c) Immunoprecipitation of p65 and PPARγ in human chondrocytes induced by 10 μg/ml poly(I:C) pretreated with or without the p38 MAPK inhibitor SB202190. (d) Immunofluorescent staining of PPARγ and p65 in normal human chondrocytes induced by 10 μg/ml poly(I:C) in the presence of the p38 MAPK inhibitor SB202190. Scale bar represents 50 μm. ***P<0.001. P-values were analyzed by one-way ANOVA