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. 2017 Nov 2;8(11):e3165. doi: 10.1038/cddis.2017.534

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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IL-33 is the mediator of dsRNA-induced MMP-1 and MMP-13 expression. (a) IL-33 expression in normal human chondrocytes treated with or without Il-33 siRNA. (b and c) Mmp-1 and Mmp-13 expression induced by 10 μg/ml poly(I:C) before or after Il-33 was silenced in human chondrocytes. (d–f) Quantification of Il-33 (d), Mmp-1 (e), and Mmp-13 (f) expression in mouse cartilage induced by poly(I:C) intra-articular injection in the presence or absence of an IL-33-neutralizing antibody. (g) Immunohistochemical analysis of type II collagen expression in mouse articular tissues in the presence or absence of an IL-33-neutralizing antibody. Scale bar represents 100 μm. (h) Safranin O staining of mouse articular tissues induced by poly(I:C) intra-articular injection in the presence or absence of an IL-33-neutralizing antibody. Scale bar represents 100 μm. *P<0.05, **P<0.01 and ***P<0.001. P-values were analyzed by t-test in (a), one-way ANOVA in (b–f)