Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Nov 2;8(11):e3162. doi: 10.1038/cddis.2017.542

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

Intact CNS astrocytes, T cells, ependymal cells, and M/Ms mainly contribute to the increasing secretion of M-CSF. (a and b) Two membranes show that the CSF cytokine profile of SCI-epoB (a) or intact-epoB (b) were unchanged in six cytokines 3 DPE. (c–i) Representative fluorescent staining images show SCI-epoB and SCI-vehicle 3 DPE. Double staining of particular cell types of CNS and M-CSF plus DAPI labeling for nuclei shows astrocytes (c), T cells (e), neurons (f), ependymal cells (g) and M/Ms (i) increase the secreting of M-CSF. Others cells of neutrophils (d) and oligodendrocytes (h) exhibit no change on M-CSF secretion. Arrows indicate examples of double-labeled cells. (j) Quantitative analysis of M-CSF expression in the CSF by ELISA. Means±S.D.; n=3 per group in (a) and (b). n=6 per group in (c)–(i). n=3 per group in (j); *P-value <0.05; **P-value <0.01; ***P-value <0.001 (one-way ANOVA)