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. 2017 Nov 2;8(11):e3162. doi: 10.1038/cddis.2017.542

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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SCI lesions polarize M/M from M2 to M1 phenotype 3 days after epoB treatment; the neutralizing antibody mix (NAM) partly reverses this polarization. (a) Representative plots showing the separating process of M/M in SCI lesions. Representative plots of M1 and M2 polarization are distinguished by (b) CD16/32 plus CD206, (c) CD86 plus CD163, and (d) TNF-α plus TGF-β in the SCI-vehicle, SCI-epoB, and SCI-epoB-NAM lesion sites 3 DPE. This experiment was conducted on the above group with the markers of (e) CD16/32 plus CD206, (f) CD86 plus CD163, and (g) TNF-α plus TGF-β 7 DPE. (h–i) Quantification of M/M polarization analyzed by CD16/32, CD86, CD163, and TNF-α at 3 DPE (h) and 7 DPE (i). Means±S.D.; n=6 per group; *P-value <0.05; **P-value <0.01; ***P-value <0.001 (one-way ANOVA)