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. 2018 Jan 19;8:1180. doi: 10.1038/s41598-018-19451-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differential gene expression in PDGFRA-overexpressing rat, mouse, and canine in situ-formed gliomas. Heatmaps representing the degree of variation and clustering of gene expression between control, normal brain tissue (red bar) and tumor tissue (blue bar). (A) RCAS/TV-A rat gliomas: there were 1,710 DEGs in total; this included 661 up-regulated genes and 1,049 down-regulated genes. Several examples of glioma-associated DEGs that were upregulated or downregulated specifically in the rat model are listed. (B) RCAS/TV-A mouse gliomas: there were 3,223 DEGs in total with 1,658 up-regulated and 1,565 down-regulated in tumor tissue compared to normal brain. Several examples of glioma-associated DEGs that were upregulated or downregulated specifically in the mouse model are listed. (C) Spontaneous canine glioma: there were 4,166 DEGs in total with 2,109 up-regulated and 2,057 down-regulated in tumor tissue compared to normal brain. Several examples of glioma-associated DEGs that were upregulated or downregulated specifically in dogs are listed. [Scale bar representing graded fold change in gene expression: red = increased expression, green = decreased expression].