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. 2018 Jan 19;8:1180. doi: 10.1038/s41598-018-19451-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Four-species DEG Venn diagrams and data summary table. (A) Relative overlap of increased (UP) and decreased (DOWN) differentially expressed genes in rat, mouse, canine and human PDGFRA-overexpressing glioma. Six examples of commonly up-regulated or down-regulated DEGs are listed in the boxes. (B) The unique and overlapping DEGs were compared by calculating the percentage of unique DEGs in the total DEG set for that species (% different) and the percentage of the common glioma DEGs represented within the total DEG set for that species (% overlap). The rat tumors showed the smallest percentage of unique DEGs, and the largest percent overlap of the common DEGs within the total rat DEG set. The human and canine tumors showed the greatest percentage of unique DEGs and lowest percent overlap of the common DEGs.