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. 2018 Jan 19;8:1194. doi: 10.1038/s41598-018-19566-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IAPs disturb the main phase transition of DMPC and 2∶1 DMPC:DMPG model membranes. DSC scans of phospholipid LUVs mixed with 4 mol% peptides. Thermograms were normalized to the lipid mass and the P′_β→L_α transition was fit to a non-two state transition with two peaks. The experimental data are represented as a black line and model fitting is in red. Thermograms for the peptide At03 added to DMPC and 2:1 DMPC:DMPG LUVs are shown in insets (a1 and a2), respectively. Thermograms depicting the effect of peptides Tc10 (insets b1 and b2), At02 (insets c1 and c2) and Cs02 (insets d1 and d2) in the main phase transition of DMPC and 2:1 DMPC:DMPG LUVs, respectively, are also depicted.