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. Author manuscript; available in PMC: 2018 Jan 20.
Published in final edited form as: Biomed Mater. 2015 Dec 23;11(1):014106. doi: 10.1088/1748-6041/11/1/014106

Figure 1.

Figure 1

A scaffold with regenerative activity was initially synthesized as a highly porous graft copolymer of type I collagen and chondroitin 6-sulfate (GAG). It was modified later by omitting the GAG (see text). Regenerative activity depends on optimization of pore diameter and half-life for degradation; a minimal density of ligands for integrins α1β1 and α2β1 is also required on the collagen surface. When the structure has been appropriately optimized to yield a so-called dermis regeneration template (DRT), the scaffold induces regeneration of skin (guinea pig, swine, human) peripheral nerves (rat) and of the conjunctiva (rabbit). (Photo by Alexandra Kourgiantaki.)