Figure 6.

Schematic Comparison of Outline-Based and Molecular Scale Views of RyR Clusters

(A and B) Schematic comparison of the outline-based view of RyR clusters (A) and the molecular-scale maps (B). The latter account for variable arrangements of RyRs, gaps in arrays and differential co-clustering with JPH2.

(C) Schematic activation probability maps of clusters highlight uniform cluster activation probability in the regularly filled array compared to the heterogeneous activation of clusters (asterisks) and expected intra-nanodomain Ca²⁺ gradients (arrow) in the molecular-scale model.