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. 2018 Jan 15;8:1823. doi: 10.3389/fimmu.2017.01823

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Copyright © 2018 Soper, Kimura, Nagaoka, Konno, Yamamoto, Koyanagi and Sato.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Type I interferons (IFN-I)-initiated signaling pathway leading to interferon-stimulated gene (ISG) expression. Cellular actions triggered by IFN-I [Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway] are indicated in purple (in italic) with arrows. Cellular organelle and the cellular molecules related to JAK/STAT pathway are indicated in green and purple, respectively. The detail of each step is described in the main text. “P” with yellow circle indicates phosphorylation.