Table 1.
Comparison between signals and leukogram data between MSP1a/OMP7/8/9 protein-immunized mice and controls mice
| Immunized | Adjuvant | Non-immunized | p | Reference | |
|---|---|---|---|---|---|
| Symptoms, animals with symptom (Total of animals)a | |||||
| Opaque fur | 0 (5) | 5 (5) | 5 (5) | nd | 0 (5) |
| Ruffled fur | 0 (5) | 5 (5) | 5 (5) | nd | 0 (5) |
| Weight loss | 0 (5) | 0 (5) | 5 (5) | nd | 0 (5) |
| Lethargy | 0 (5) | 5 (5) | 5 (5) | nd | 0 (5) |
| Death | 0 (5) | 0 (5) | 2 (5) | nd | 0 (5) |
| Leukogramb | |||||
| Leucocytes | 5600.0 (529.2)* | 7266.7 (1814.8) | 7733.3 (1222.0)* | 0.0415 | 3483.3 (2119.7) |
| Lymphocytes | 2053.5 (835.3) | 2640.0 (254.4) | 2242.7 (671.0) | 0.3967 | 2223.4 (778.2) |
| Monocytes | 130.0 (29.5)* | 180.7 (112.9) | 253.3 (12.2)* | 0.0071 | 210.7 (27.2) |
| Neutrophils | 3318.7 (370.1)* | 4457.3 (1411.7) | 5104.0 (595.9)* | 0.0380 | 2014.0 (1396.4) |
| Red cells, millions/mm3 | 5.6 (0.5) | 5.5 (0.9) | 6.4 (0.6) | 0.0631 | 5.6 (0.6) |
| Hemoglobin g/dL | 16.8 (1.4) | 16.7 (2.8) | 19.5 (1.9) | 0.1324 | 16.9 (1.8) |
| Hematocrit % | 50.3 (4.0) | 50.3 (8.3) | 58.7 (5.8) | 0.1303 | 50.7 (5.5) |
| MCV/mm3 | 90.3 (0.6) | 90.7 (0.6) | 91.0 (0.0) | 0.2605 | 90.3 (0.6) |
| MHV/mm3 | 30.0 (0.0) | 30.0 (0.0) | 30.0 (0.0) | 0.9999 | 30.0 (0.0) |
| MCHC/mm3 | 33.0 (0.0) | 33.0 (0.0) | 33.0 (0.0) | 0.9999 | 33.0 (0.0) |
| Platelets, millions/mm3 | 323.7 (97.0) | 403.3 (139.5) | 281.3 (138.6) | 0.6447 | 309.7 (45.6) |
| Creatinine, mg/dL | 1.2 (0.5) | 1.2 (0.4) | 1.2 (0.5) | 0.9854 | 1.1 (0.5) |
| Urea, mg/dL | 56.3 (33.6) | 55.0 (8.9) | 52.0 (18.5) | 0.9999 | 61.3 (20.4) |
nd: not done.
* significance found by Kruskal Wallis T-test.
aAnimals with symptom (Total of animals).
bFor leukogram data, only three animals have been used in each parameter. Mean (standard deviation).