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. 2018 Jan 19;17:11. doi: 10.1186/s12943-017-0751-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — miR-22 inhibits SW480 proliferation and migration in vitro by targeting HuR. a, c and d miR-22 inhibits SW480 proliferation. a: CCK-8 assay; c and d: EdU assay. b, e and f Recovery experiments indicated that the suppression of SW480 proliferation by miR-22 was due to its inhibitory effect on HuR. b: CCK-8 assay; e and f: EdU assay. g and h Transwell assays revealed that miR-22 could inhibit SW480 migration. g and i Recovery experiments indicated that the suppression of SW480 migration by miR-22 was due to its inhibitory effect on HuR. **P < 0.01; ***P < 0.001