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. 2018 Jan 15;8:1926. doi: 10.3389/fimmu.2017.01926

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Copyright © 2018 Nagala, McKenzie, Richards, Sharma, Thomson, Mastroeni and Crocker.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Siglec-E-deficient mice show enhanced growth of Salmonella Typhimurium following intravenous infection. (A) Wild-type (WT) and KO1 mice on a Balb/c background and (B) WT and KO1 on a C57BL/6J background and R126D mice were infected with S. Typhimurium M525P and liver and spleen CFU determined from groups of 4–8 mice at the indicated time points. Data in (A) show mean values ± 1 SD and data in (B) show values for individual mice. Statistical analysis was performed by Student’s t-test: *p < 0.05; **p < 0.005; ***p < 0.0005.