Table 2.
Dose effect of TNF-α level and the risk of PEG
| TNF-α (pg/mL) |
Cases (n=49) no (%) |
Controls (n=88) no (%) |
Odds ratio | 95% confidence interval | p-value |
|---|---|---|---|---|---|
| By median | |||||
| ≤0.5 | 14 (28.5) | 55 (62.5) | Reference | – | – |
| >0.5 | 35 (71.4) | 33 (37.5) | 4.16 | 1.95–8.86 | 0.00017 |
| By quartilesa | |||||
| 0 | 14 (28.5) | 51 (57.9) | Reference | – | – |
| 0.1–3.8 | 5 (10.2) | 33 (37.5) | 0.5 | 0.18–1.67 | 0.31 |
| >3.8 | 30 (61.2) | 4 (4.5) | 27.32 | 8.23–90.6 | 1.08e-10 |
Notes:
a
First quartile (<25th percentile); interquartile (25th–75th percentile); third quartile (>75th percentile). Overall dose response was significant (χ2=57.07, df=2, p=0).
Abbreviations: TNF-α, tumor necrosis factor alpha; PEG, pseudoexfoliation glaucoma.