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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: J Steroid Biochem Mol Biol. 2017 Jul 20;177:140–148. doi: 10.1016/j.jsbmb.2017.07.009

Figure 6. Model of calcitriol-mediated reduction in p-STAT1 and IFN-γ in T-LGLL.

Figure 6

In TL-1 cells supplemented with IL-2, there is a detectable level of VDR and high baseline STAT1 Y701 phosphorylation and IFN-γ production. Within 4 h of calcitriol treatment of TL-1, p-STAT1 and IFN-γ are reduced while VDR is increased. This effect is sustained at 24 h and the final outcome is decreased IFN-γ production that correlates with increased VDR protein. p-STAT1 levels are not dependent on the VDR increase and do not correlate with IFN-γ reduction, showing that p-STAT1 and IFN-γ decreases are mediated by different mechanisms.