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. Author manuscript; available in PMC: 2018 Sep 21.
Published in final edited form as: Mol Psychiatry. 2017 Jul 20;23(7):1643–1651. doi: 10.1038/mp.2017.129

Figure 4. Changes in allele-specific and total expression of hippocampal Dio3 and Igf2 are sex- and treatment-dependent.

Figure 4

Allele-specific expression in adult male hippocampus was determined by pyrosequencing using the already verified SNPs a) Dio3 (N=4–10/prenatal diet/neonatal treatment) and b) Igf2 (N=3–11/prenatal diet/neonatal treatment). Schematic representation of the maternal and the paternal allelic contributions to the total hippocampal expression of c) Dio3 and d) Igf2 (drawn not to the scale). e) Effects of neonatal metformin treatment on FAE-altered transcript levels of hippocampal Dio3 in adult offspring (N=4–8/sex/prenatal diet/neonatal treatment). f) Total transcript levels of Igf2 in the hippocampus of adult offspring in response to FAE and neonatal T4 treatment (N = 8–20/prenatal diet/neonatal treatment, sex combined). Details are as described in Figure 1.