Table 5.

Risk of bias in animal studies.

Reference	Random allocation	Allocation concealment	Blinding	Inclusion/exclusion criteria	Sample size calculation	Compliance with animal requirements	Conflicts of interests disclosed	Statistical model explained	Animals without comorbidity	Test animal details	Every animal accounted	Dose-response model	Optimal time window used	Total
Abdel-Baki et al. (37)	No	No	No	No	No	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	7/13
Chen et al. (38)	Yes	No	No	No	No	Yes	No	Yes	Yes	Yes	Yes	Yes	Yes	8/13
Du et al. (39)	Yes	No	No	Yes	No	Yes	Yes	Yes	Yes	Yes	Yes	No	Yes	9/13
Eakin et al. (40)	Yes	No	No	No	No	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	9/13
Ellis et al. (41)	No	No	No	No	No	Yes	No	Yes	No	No	Yes	Yes	Yes	5/13
Ewert et al. (42)	Yes	No	No	No	No	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	9/13
Gunther et al. (43)	Yes	No	No	No	No	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	9/13
Haber et al. (44)	No	No	No	No	No	Yes	No	Yes	Yes	Yes	No	Yes	Yes	6/13
Hicdonmez et al. (45)	Yes	No	No	No	No	Yes	No	Yes	Yes	Yes	Yes	Yes	Yes	8/13
Kawoos et al. (46)	No	No	No	No	No	Yes	Yes	Yes	Yes	Yes	Yes	Yes	No	7/13
Naziroglu et al. (47)	Yes	No	No	No	No	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	9/13
Pandya et al. (48)	Yes	Yes	Yes	No	No	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	10/13
Senol et al. (20)	Yes	No	No	No	No	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	8/13
Silva et al. (49)	No	No	No	No	No	Yes	No	No	No	No	No	Yes	No	2/13
Thomale et al. (50)	No	No	No	No	No	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	8/13
Thomale et al. (51)	Yes	No	No	No	No	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	9/13
Xiong et al. (52)	No	No	No	No	No	Yes	No	Yes	Yes	Yes	No	Yes	Yes	6/13
Xiong et al. (53)	No	No	No	No	No	Yes	No	Yes	Yes	Yes	No	Yes	Yes	6/13
Yi and Hazell (54)	No	No	No	No	No	Yes	No	Yes	Yes	Yes	Yes	Yes	Yes	7/13
Yi et al. (55)	No	No	No	No	No	Yes	No	Yes	Yes	Yes	Yes	Yes	Yes	7/13
	10/20	1/20	1/20	1/20	0/20	20/20	11/20	20/20	18/20	15/20	14/20	19/20	18/20