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. Author manuscript; available in PMC: 2018 Jan 21.
Published in final edited form as: J Toxicol Sci. 2017;42(3):343–348. doi: 10.2131/jts.42.343

Table 3.

Induction of drug oxidation activities of cultured BeWo cells in the modified condition.

drug
hydroxylation		 untreated treated with
phenobarbital rifampicin thalidomide
pmol product formed/h/106 cells
bupropion 2.9 ± 0.3 3.3 ± 0.8 2.3± 0.9 2.8 ± 0.7
midazolam (1´) 16 ± 9 32 ± 11 27 ± 10 60 ± 10*
midazolam (4) 1.7 ± 0.2 1.6 ± 0.1 1.7 ± 0.1 1.7 ± 0.1
thalidomide (5) 0.23 ± 0.05 0.34 ± 0.09 0.33 ± 0.09 0.57 ± 0.18*

Data are presented as means and SD values of triplicate determinations. BeWo cells were cultured in the modified media containing 5% (v/v) charcoal-stripped fetal bovine serum by phenobarbital, rifampicin, and thalidomide with 20 µM rifampicin, 2000 µM phenobarbital, or 1000 µM thalidomide for 72 h. Other details are as in the legend for Table 2.

*

p < 0.05, one way ANOVA with Bonferroni post tests compared to untreated group.