Table 3.
Laboratory Data and Biomarkers
| Lab Value | Patients with ReA (n=32) Mean ± SD | Controls (n=32) Mean ± SD | p-value | Univariate β coeff. (95% CI) | Age-and-sex adjusted β coeff. (95% CI) |
|---|---|---|---|---|---|
| Sedimentation rate | 21.44 ± 25.25 | 20.19±23.11 | NS | −1.25 (−13.35, 10.85) | 2.66 (−9.14, 14.46) |
| Total cholesterol | 153.94±39.62 | 188.78±48.76 | 0.0008 | 34.84 (12.64, 57.04) | 32.47 (9.92, 55.01) |
| High density lipoprotein | 55.76±15.30 | 60.07±17.43 | NS | 4.31 (−3.90, 12.50) | 5.60 (−2.81, 14.01) |
| Low density lipoprotein | 71.8±34.0 | 89.33±31.71 | 0.045 | 17.53 (1.12 33.96) | 15.46 (−1.50, 32.41) |
| Triglycerides | 131.53±49.91 | 180.06±115.80 | NS | 48.53 (3.97, 93.09) | 40.10 (−3.60, 83.8) |
| Hemoglobin | 5.74±1.68 | 5.25±0.73 | NS | −0.48 (−1.13, 0.16) | −0.28 (−0.89, 0.33) |
| Glucose | 95.94±41.65 | 91.88±37.37 | NS | −4.06 (−23.84, 15. 71) | −0.90 (−20.84 19.04) |
| Cathepsin K (ng/mL) | 2.70±0.95 | 2.17±0.61 | 0.028 | −0.53 (−0.93, −0.13) | −0.51 (−0.92, −0.09) |
| Creatinine (pg/mL) | 0.73 ± 0.14 | 0.78 ± 0.17 | NS | 0.05 (−0.03, 0.13) | 0.004 (−0.05, 0.06) |
| hsCRP (mg/dL) | 4.17±5.34 | 2.77 ± 3.87 | 0.03 | −1.40 (−3.76, 0.96) | −1.11 (−3.54, 1.33) |
| DKK-1(pg/mL) | 3416.16 ± 1388.72 | 3069.59 ± 1204.33 | NS | −346.56 (−996.13, 303.00) | −106.40 (−725.51, 512.71) |
| MMP-3 (ng/mL) | 14.14 ±9.16 | 13.07 ± 6.58 | NS | −1.08 (−5.06 2.91) | −3.0 (−6.42, 0.43) |
| OPG (pmol/L) | 6.12 ±1.84 | 5.24 ± 1.27 | NS | −0.88(−1.67, −0.09) | −0.65 (−1.42, 0.13) |
| Sclerostin (pg/mL) | 179.73 ±75.57 | 171.00 ± 46.55 | NS | −8.72 (−40.09, 22.64) | −2.98 (−32.52, 26.56) |
| sRANKL (pmol/L) | 530.88 ± 511.01 | 778.63 ± 713.17 | NS | 247.74 (−62.39, 557.77) | 298.18 (−9.72, 606.09) |
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| HLA typing | |||||
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| HLA-A2 (%) | 14 (44 %) | 20 (63 %) | NS | ||
| HLA-B35 (%) | 23 (72 %) | 19 (59 %) | NS | ||
| HLA-C7 (%) | 17 (53 %) | 17 (53 %) | NS | ||
| HLA-B27 (%) | 2 (6 %) | 2 (6 %) | NS | ||
| HLA-B15 (%) | 2 (6 %) | 2 (6 %) | NS | ||
*
p-values were generated using the Wilcoxan Rank Sum test for non-parametric data.