Table 3.

Immune, Inflammatory, Metabolic, and Coronary Plaque Parameters among Non-HIV-Infected and HIV-Infected Women Stratified by Within-Group Median Epicardial Adipose Tissue Volume

	Non-HIV-Infected Below Median EAT Volume (n=13)	HIV-Infected Below Median EAT Volume (n=27)	Non-HIV-Infected Above Median EAT Volume (n=14)	HIV-Infected Above Median EAT Volume (n=28)	Overall P Value
Markers of Monocyte/Macrophage Activation*
MCP-1, pg/mL	166 ± 31	235 ± 22	249 ± 31	262 ± 22	0.10
CXCL10, pg/mL	131 ± 60	285 ± 43	179 ± 60	305 ± 42	0.02a,c,f
sCD163, ng/mL	984 ± 237	1642 ± 171	1506 ± 237	1896 ± 167	0.004a,c
sCD14, ng/mL	1594 ± 406	2021 ± 293	1310 ± 406	2488 ± 287	0.03f
Inflammatory Markers*
hsIL6, pg/mL	1.68 ± 0.32	1.56 ± 0.25	1.94 ± 0.32	2.20 ± 0.24	0.32
Lp-PLA2, nmol/min/mL	135 ± 14	174 ± 10	168 ± 14	176 ± 10	0.04a,b,c
Plaque Characteristics**
Presence of coronary plaque, %	23	40	54	33	0.41
Segments with noncalcified plaque, %	33 ± 19 [0 (0,100)]	71 ± 10 [71 (63,100)]	19 ± 13 [0 (0,44)]	78 ± 12 [88 (54,100)]	0.009 (0.047)d,f
Segments with mixed plaque, %	13 ± 16 [0 (0,40)]	27 ± 9 [25 (0,33)]	51 ± 11 [42 (31,75)]	17 ± 10 [0 (0,33)]	0.13 (0.13)
Segments with calcified plaque, %	53 ± 14 [60 (0,100)]	3 ± 8 [0 (0,0)]	40 ± 9 [33 (0,67)]	5 ± 9 [0 (0,13)]	0.003 (0.01)a,c,d,f
Metabolic Parameters
Fasting glucose, mg/dL	78 ± 10	91 ± 7	88 ± 10	90 ± 7	0.75
Triglycerides, mg/dL	85 ± 17	113 ± 12	134 ± 17	104 ± 12	0.24

Abbreviations: EAT, epicardial adipose tissue; MCP-1, monocyte chemoattractant protein-1; CXCL10, C-X-C motif chemokine 10; sCD163, soluble CD163; sCD14, soluble CD14; hsIL6, high sensitivity interleukin 6; Lp-PLA₂, lipoprotein-associated phospholipase A₂

^*Data reported as mean ± standard error; overall P value by ANOVA. Data for markers of monocyte/macrophage activation and generalized inflammation are presented prior to log transformation only for purposes of clinical interpretation; the appropriate statistical test was applied after log-transformation.

^**For plaque segment data, non-normally distributed data also reported as [median (IQR)]; overall P value by Kruskal-Wallis test.

^aP < 0.05 Non-HIV-Infected Below Median EAT vs. HIV-Infected Below Median EAT

^bP < 0.05 Non-HIV-Infected Below Median EAT vs. Non-HIV-Infected Above Median EAT

^cP < 0.05 Non-HIV-Infected Below Median EAT vs. HIV-Infected Above Median EAT

^dP < 0.05 HIV-Infected Below Median EAT vs. Non-HIV-Infected Above Median EAT

^eP < 0.05 HIV-Infected Below Median EAT vs. HIV-Infected Above Median EAT

^fP < 0.05 Non-HIV-Infected Above Median EAT vs. HIV-Infected Above Median EAT