Table 3.
Weighted* risk ratios (RRs) and 95% confidence intervals (CI) of obstructive sleep apnea (OSA) categories with dementia, mild cognitive impairment (MCI), and dementia or MCI due to AD: The Atherosclerosis Risk in Communities (ARIC) study, 1996–2013
| OSA Categories (AHI) | ||||
|---|---|---|---|---|
|
|
||||
| N | Normal (<5) 581 |
Mild (5 to <15) 312 |
Moderate (15 to <30) 132 |
Severe (>30) 58 |
| Dementia or MCI, n | 126 | 83 | 41 | 19 |
| Model 1 | 1 | 1.10 (0.86, 1.39) | 1.17 (0.86, 1.57) | 1.43 (0.99, 2.07) |
| Model 2 | 1 | 1.09 (0.86, 1.39) | 1.14 (0.84, 1.56) | 1.35 (0.91, 2.01) |
| Model 3 | 1 | 1.08 (0.85, 1.37) | 1.16 (0.85, 1.59) | 1.30 (0.87, 1.93) |
| Dementia, n | 28 | 20 | 4 | 5 |
| Model 1 | 1 | 1.31 (0.73, 2.37) | 0.45 (0.16, 1.26) | 2.35 (1.06, 5.18) |
| Model 2 | 1 | 1.49 (0.83, 2.66) | 0.50 (0.18, 1.39) | 2.51 (1.09, 5.79) |
| Model 3 | 1 | 1.34 (0.76, 2.37) | 0.53 (0.18, 1.49) | 2.19 (0.92, 5.19) |
| MCI, n | 98 | 63 | 37 | 14 |
| Model 1 | 1 | 1.07 (0.80, 1.42) | 1.31 (0.95, 1.82) | 1.36 (0.84, 2.18) |
| Model 2 | 1 | 1.05 (0.78, 1.41) | 1.27 (0.90, 1.80) | 1.30 (0.78, 2.18) |
| Model 3 | 1 | 1.04 (0.78, 1.40) | 1.29 (0.91, 1.83) | 1.24 (0.74, 2.09) |
| AD dementia or MCI, n | 81 | 55 | 29 | 14 |
| Model 1 | 1 | 1.17 (0.85, 1.60) | 1.32 (0.90, 1.93) | 1.66 (1.03, 2.68) |
| Model 2 | 1 | 1.15 (0.83, 1.58) | 1.23 (0.82, 1.84) | 1.46 (0.86, 2.46) |
| Model 3 | 1 | 1.13 (0.82, 1.55) | 1.25 (0.83, 1.87) | 1.37 (0.82, 2.30) |
*
Inverse-probability weighting was used.
Model 1: Relative risk regression adjusted for age, sex, center, education level, and APOE
Model 2: Model 1 + additional adjustment for body mass index, smoking status, and leisure time physical activity
Model 3: Model 2 + additional adjustment for diabetes, antihypertensive medications, C-reactive protein, and systolic blood pressure