Table 5.
Weighted* risk ratios (RRs) and 95% confidence intervals (CI) of habitual sleep duration categories with dementia, mild cognitive impairment (MCI), and dementia or MCI due to AD: The Atherosclerosis Risk in Communities (ARIC) study, 1996–2013
| Average Sleep Duration (hours) | ||||
|---|---|---|---|---|
|
|
||||
| N | <7 257 |
7 to <8 435 |
8 to <9 330 |
>9 59 |
| Dementia or MCI, n | 73 | 100 | 81 | 13 |
| Model 1 | 1.28 (0.98, 1.66) | 1.09 (0.85, 1.40) | 1 | 0.89 (0.56, 1.40) |
| Model 2 | 1.28 (0.99, 1.66) | 1.08 (0.84, 1.38) | 1 | 0.90 (0.57, 1.42) |
| Model 3 | 1.26 (0.97, 1.63) | 1.08 (0.84, 1.39) | 1 | 0.86 (0.54, 1.36) |
| Dementia, n | 17 | 21 | 15 | 4 |
| Model 1 | 2.00 (1.03, 3.86) | 1.39 (0.73, 2.66) | 1 | 1.69 (0.75, 3.78) |
| Model 2 | 2.04 (1.08, 3.85) | 1.33 (0.69, 2.56) | 1 | 1.56 (0.67, 3.67) |
| Model 3 | 1.89 (1.01, 3.51) | 1.42 (0.75, 2.70) | 1 | 1.53 (0.69, 3.39) |
| MCI, n | 56 | 79 | 66 | 9 |
| Model 1 | 1.18 (0.86, 1.63) | 1.01 (0.75, 1.35) | 1 | 0.74 (0.40, 1.34) |
| Model 2 | 1.18 (0.86, 1.63) | 1.00 (0.75, 1.34) | 1 | 0.74 (0.40, 1.36) |
| Model 3 | 1.19 (0.86, 1.63) | 1.00 (0.75, 1.34) | 1 | 0.73 (0.40, 1.32) |
| AD dementia or MCI, n | 50 | 65 | 55 | 8 |
| Model 1 | 1.25 (0.88, 1.76) | 1.01 (0.73, 1.41) | 1 | 0.83 (0.44, 1.58) |
| Model 2 | 1.25 (0.89, 1.76) | 1.01 (0.73, 1.41) | 1 | 0.80 (0.42, 1.52) |
| Model 3 | 1.26 (0.89, 1.77) | 1.01 (0.73, 1.41) | 1 | 0.75 (0.40, 1.43) |
*
Inverse-probability weighting was used.
Model 1: Relative risk regression adjusted for age, sex, center, education level, and APOE
Model 2: Model 1 + additional adjustment for body mass index, smoking status, and leisure time physical activity
Model 3: Model 2 + additional adjustment for diabetes, antihypertensive medications, C-reactive protein, and systolic blood pressure