Immunoblot analysis of APP, BACE1, Aβ42, and CTFβ/α in the cortex and hippocampus in 6 months old WT-CB2R-KO and TG-CB2R-KO mice treated with the vehicle or JZL184. **P<0.01 compared with the WT-CB2R-KO vehicle control; #P<0.05, ##P<0.01 compared with the TG-CB2R-KO vehicle control. (ANOVA with Fisher’s PLSD test, n=3 mice per group).