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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Mol Neurobiol. 2017 Jul 21;55(6):4802–4810. doi: 10.1007/s12035-017-0689-x

Figure 4. Inactivation of MAGL improves spatial learning and memory in TG-CB2R-KO mice.

Figure 4

A) The Morris water maze test was performed in 6-month-old WT-CB2R-KO and TG-CB2R-KO mice that received vehicle or JZL184. The test was conducted one week following the cessation of the treatment. Mice received visible platform training for 3 days followed by 7 days of invisible platform training. B) Number of platform crossing during the probe test. The probe trial was conducted 24 hrs after 7 days of acquisition training. During the probe test, the platform was removed from the water tank. Number of times crossing the target zone was recorded. C) The percentage of time spent in search of the target zone in each quadrant during the probe trial. **<0.01, compared with the WT-CB2R-KO vehicle control; ##P<0.01 compared with the TG-CB2R-KO vehicle (ANOVA with Bonferroni post-hoc test, n=10 to 13 mice/group).