Figure 5. Inactivation of MAGL prevents deterioration in expression of synaptic molecules in TG-CB2R-KO mice.
Immunoblot analysis of hippocampal expression of PSD95, AMPA (GluR1 and GluR2), and NMDA (NR1, NR2A and NR2B) receptor subunits in 6 months old WT-CB2R-KO and TG-CB2R-KO mice treated with vehicle or JZL184. *P<0.05; **P<0.01 compared with the WT-CB2R-KO vehicle control, ##P<0.01 compared with the TG-CB2R-KO vehicle control (ANOVA with Fisher’s PLSD test, n=3 mice per group).