Table 3.
ROI Visit Region |
Cluster size (voxels) |
x | y | z | SPM {t} |
Voxel p (FWE - corrected) |
---|---|---|---|---|---|---|
CC | ||||||
Visit 1 | ||||||
No activation k ≥ 15 | – | – | – | – | – | – |
Visit 2 | ||||||
Right middle cingulate cortex | 150 | 6 | 12 | 45 | 8.45 | <0.0005 |
Right anterior cingulate cortex | 15 | 12 | 36 | 15 | 5.18 | <0.0005 |
Visit 1 > Visit 2 | ||||||
No activation k ≥ 15 | – | – | – | – | – | – |
Visit 2 > Visit 1 | ||||||
Right anterior cingulate cortex | 20 | 3 | 18 | 24 | 5.41 | <0.0005 |
Right anterior cingulate cortex | 23 | 9 | 30 | 18 | 5.21 | <0.0005 |
FRONTAL | ||||||
Visit 1 | ||||||
Left superior frontal gyrus | 65 | -30 | -3 | 69 | 9.51 | <0.0005 |
Right inferior frontal gyrus (p. triangularis) | 19 | 45 | 12 | 24 | 8.48 | <0.0005 |
Visit 2 | ||||||
Right inferior frontal gyrus (p. opercularis) | 575 | 42 | 9 | 27 | 10.75 | <0.0005 |
Left middle frontal gyrus | 217 | -24 | -6 | 51 | 10.08 | <0.0005 |
Left precentral gyrus | 19 | -45 | 9 | 36 | 7.87 | <0.0005 |
Visit 1 > Visit 2 | ||||||
No activation k ≥ 15 | – | – | – | – | – | – |
Visit 2 > Visit 1 | ||||||
Right middle frontal gyrus | 88 | 48 | 9 | 54 | 6.94 | <0.0005 |
Right superior frontal gyrus | 25 | 24 | 12 | 66 | 6.58 | <0.0005 |
The statistical threshold was initially set at p < 0.05 for cluster level family-wise-error (FWE), and p < 0.0005 for voxel level FWE (corrected for multiple comparisons) with a minimum cluster extent k = 15 contiguous voxels. Bolded results indicate values that survived the Monte Carlo simulation minimum cluster extent (k = 91).